Difference between t3 and t4

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difference between t3 and t4

Thyroid Hormone Production


Thyroid hormones are two hormones produced and released by the thyroid gland , namely triiodothyronine T 3 and thyroxine T 4. They are tyrosine -based hormones that are primarily responsible for regulation of metabolism. T 3 and T 4 are partially composed of iodine. A deficiency of iodine leads to decreased production of T 3 and T 4 , enlarges the thyroid tissue and will cause the disease known as simple goitre. The major form of thyroid hormone in the blood is thyroxine T 4 , which has a longer half-life than T 3.

Your thyroid gland is a small gland, normally weighing less than one ounce, located in the front of the neck. It is made up of two halves, called lobes, that lie along the windpipe trachea and are joined together by a narrow band of thyroid tissue, known as the isthmus. The thyroid is situated just below your "Adams apple" or larynx. During development inside the womb the thyroid gland originates in the back of the tongue, but it normally migrates to the front of the neck before birth. Sometimes it fails to migrate properly and is located high in the neck or even in the back of the tongue lingual thyroid.

The thyroid gland, located in the anterior neck, consists of two types of cells: follicular cells, which produce T3 and T4, and parafollicular cells.
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Furthermore, T4 is converted into T3 by an enzyme called iodothyronine deiodinase, mainly in the liver. Therefore, T3 and T4 are the two forms of thyroid hormone that regulates the metabolism. T3 is known as triiodothyronine while T4 is known as thyroxine. T3 triiodothyronine is the active form of the thyroid hormone that can readily go into the cells of the body. That means every cell of the body has thyroid receptors. TSH thyroid-stimulating hormone is the pituitary hormone, which stimulates the thyroid gland for the production of T4.

Thyroxine T4 and triiodothyronine T3 are important hormones produced by the thyroid gland that are essential for brain and physical development in infants and for metabolic activity in adults. Health care professionals should know how to monitor these hormones to prevent emergencies and improve outcomes. The thyroid gland, located in the anterior neck, consists of two types of cells: follicular cells, which produce T3 and T4, and parafollicular cells, which produce and secrete thyrocalcitonin also called calcitonin. T4 is produced solely by the thyroid gland. This occurs primarily in the liver and kidney, but T3 is also produced in some, if not all tissues. T3 and T4 production is regulated by thyroid stimulating hormone TSH secreted by the pituitary gland, which is in turn regulated by thyrotropin-releasing hormone TRH secreted by the hypothalamus.

This test measures the level of the hormone thyroxine T4 in your blood. The hormone is made by your thyroid gland. The thyroid is a butterfly-shaped gland near the base of your throat, above your collarbones. The thyroid gland makes T4 in response to thyroid-stimulating hormone TSH. TSH is made by the pituitary gland in your brain. Because T4 is converted into another thyroid hormone called T3 triiodothyronine , free T4 is the more important hormone to measure. Any changes show up in T4 first.

Thyroid hormones

How Your Thyroid Works

The thyroid produces a hormone called triiodothyronine, known as T3. It also produces a hormone called thyroxine, known as T4. Most of the T3 in your body binds to protein. The most common kind of T3 test, known as the T3 total test, measures both kinds of T3 in your blood. By measuring the T3 in your blood, your doctor may be able to determine if you have a thyroid problem.


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