Atherosclerotic calcification of the aorta

Aortic Valve Stenosis

atherosclerotic calcification of the aorta

Is aortic valve calcification a sign I am developing heart disease? Aortic valve calcification is a condition in which calcium deposits form on the aortic valve in the heart. Aortic valve calcification may be an early sign that you have heart disease, even if you don't have any.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs. What risks does calcification in the aorta cause? Anthony L.

Computed tomography CT -based measures of calcification in the abdominal aorta are strong predictors of heart attacks and other adverse cardiovascular events—stronger even than the widely used Framingham risk score, according to a new study published in the journal Radiology. Cardiovascular diseases are the leading cause of death worldwide. Of these deaths, heart disease and stroke are the deadliest. Effective measures of cardiovascular disease risk are crucial in predicting which patients are most in need of early interventions like diet and lifestyle changes, or medications to lower cholesterol. O'Connor, M.

We hypothesize that chelating agents, such as disodium ethylene diamine tetraacetic acid EDTA , diethylene triamine pentaacetic acid DTPA and sodium thiosulfate STS might reverse elastin calcification by directly removing calcium Ca from calcified tissues into soluble calcium complexes. The tissue architecture was not altered during chelation. In the animal model of aortic elastin-specific calcification, we further show that local periadventitial delivery of EDTA loaded in to poly lactic-co-glycolic acid PLGA nanoparticles regressed elastin specific calcification in the aorta. Collectively, the data indicate that elastin-specific medial vascular calcification could be reversed by chelating agents. Pathological calcification is defined as ectopic deposition of poorly crystalline hydroxyapatite in soft tissues as observed in blood vessels and cardiac valves [ 1 ], The two areas of calcification seen in arterial tissues include intimal calcification, detected in atherosclerotic plaque present in the intima, and medial calcification of elastic layers MAC , detected in patients with diabetes, renal failure, and old age [ 2 ]; which is independent of atherosclerosis. Its presence correlates well with risk of cardiovascular events and leg amputation in diabetic patients [ 3 ].



What risks does calcification in the aorta cause?

This limits the amount of blood pumped from your heart into, and then out of, the aorta. This is the main artery of the body. Aortic valve stenosis generally produces symptoms only once it progresses.

Aortic Stenosis

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